Department of Chemistry

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Yiming Wang

Assistant Professor

Contact

Chevron Science Center, Room 505
219 Parkman Avenue

Pittsburgh, PA 15260

Research Overview

The Wang group will develop new catalysts, conditions, and reagents for organic synthesis.  Investigations will focus on the development of methods for the activation and functionalization of unreactive but widely available carbon sources, as well as the stereoselective formation of weakly polarized carbon-carbon and carbon-heteroatom bonds under functional group tolerant and operationally simple catalytic conditions.  Non-noble transition metal activation of hydrocarbons and ion pairing control of regio- and stereochemical outcome will be pursued as strategies for selective transformations of value to the synthesis of compounds of interest to the biomedical or materials sciences.  Tools of physical organic chemistry and computational investigations will be applied to uncover mechanistic insights for rational optimization of chemical transformations.

Awards

  • National Institutes of Health Ruth L. Kirschstein NRSA Individual Postdoctoral Fellowship (2014-2017)
  • Outstanding Graduate Student Instructor Award, UC Berkeley (2011)
  • Phi Beta Kappa, Harvard College (2008)

Publications

“Enantioselective CuH-Catalyzed Hydroallylation of Vinylarenes,” Wang, Y.-M.; Buchwald, S. L.  , J. Am. Chem. Soc., Vol. 138, 2016, Pages 5024
“Enantioselective Synthesis of Carbo- and Heterocycles through a CuH-Catalyzed Hydroalkylation Approach,” Wang, Y.-M.; Bruno, N. C.; Placeres, Á. L.; Zhu, S.; Buchwald, S. L. , J. Am. Chem. Soc., Vol. 137, 2015, Pages 10524-10527
“An In Situ Directing Group Strategy for Chiral Anion Phase-Transfer Fluorination of Allylic Alcohols,” Zi, W.(+); Wang, Y.-M.(+); Toste, F. D. (+): Equally contributing authors. , J. Am. Chem. Soc., Vol. 136, 2014, Pages 12864-12867
“Enantioselective Halocyclization using Reagents Tailored for Chiral Anion Phase-Transfer Catalysis,” Wang, Y.-M.; Wu, J.; Hoong, C.; Rauniyar, V.; Toste, F. D. , J. Am. Chem. Soc., Vol. 134, 2012, Pages 12928-12931
“Chiral (Acyclic Diaminocarbene)Gold(I)-Catalyzed Dynamic Kinetic Asymmetric Transformation of Propargyl Esters,” Wang, Y.-M.; Kuzniewski, C. N.; Rauniyar, V.; Hoong, C.; Toste, F. D. , J. Am. Chem. Soc., Vol. 133, 2011, Pages 12972-12975