Department of Chemistry

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Toby Chapman

Professor Emeritus

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1203B Chevron

Chevron Science Center, 219 Parkman Avenue


Pittsburgh, PA 15260
412-624-8250

Research Overview

Polymer Chemistry: Synthesis and Chemistry of New Polymeric Materials and Biopolymers

Professor Chapman ís current research is in the area of polymer synthesis, particularly polymers with potential biomedical applications. His research is currently centering on dendritic polymers made from naturally occurring amino acids and other metabolites to be used for applications ranging from drug delivery and gene therapy to tissue engineering and artificial blood. We have been focusing on amphiphilic dendritic polymers based on the amino acid lysine and also containing linear polymeric moieties. We refer to these polymers as "hydraamphiphiles" We are studying their ability to carry hydrophobic drugs either by forming micelles in water and absorbing the drugs or by stabilizing oil-in-water emulsions which function as the drug carriers. The polymers are also being studied as vectors for carrying DNA into cells and as modifiers of the mechanical properties of ceramic materials to be used as prostheses.

A second interest is the synthesis of fully conjugated dendrimers. These would serve as the basis of novel, organic "quantum dots" with very strong nonlinear optical properties and as a potential photoredox catalysts. In the latter capacity, these would model chloroplasts and potentially lead to a unique catalyst for splitting water photochemically.

A third interest remains the synthesis of biocompatible coatings based on polyurethanes. This involves synthesizing polyurethanes with biobenign hydrolysis products as well as creating backbone sites for modification in a way to promote the adhesion of natural surface cells.

Publications

“Mechanical degradation of drag reducing polymers in suspensions of blood cells and rigid particles,” Marhefka JN, Velankar SS, Chapman TM, Kameneva MV, BIORHEOLOGY, Vol. 45, 2008, Pages 599-609
“Poly(N-vinylformamide) - A drag-reducing polymer for biomedical applications,” Marhefka JN, Marascalco PJ, Chapman, TM, BIOMACROMOLECULES, Vol. 7, 2006, Pages 1597-1603
“Design and synthesis of hydroxyapatite composites containing an mPEG-dendritic poly(L-lysine) star polycaprolactone,” Boduch-Lee KA, Chapman TM, Petricca SE, Marra KG, Kumta P, MACROMOLECULES, Vol. 37, 2004, Pages 8959-8966
“Synthesis and characterization of alkylated n-vinylformamide monomers and their polymers,” Shi LJ, Boduch-Lee KA, Henssler JT, Beckman EJ, Chapman TM, JOURNAL OF POLYMER SCIENCE PART A-POLYMER CHEMISTRY, Vol. 42, 2004, Pages 4994-5004
“Matrix-assisted laser desorption/ionization mass spectrometry of discrete mass poly(butylene glutarate) oligomers,” Williams JB, Chapman TM, Hercules DM, ANALYTICAL CHEMISTRY, Vol. 75, 2003, Pages 3092-3100
“Synthesis of discrete mass poly(butylene glutarate) oligomers,” Williams JB, Chapman TM, Hercules DM, MACROMOLECULES, Vol. 36, 2003, Pages 3898-3908
“Poly(ethylene glycol)-block-poly(N-vinylformamide) copolymers synthesized by the RAFT methodology,” Shi LJ, Chapman TM, Beckman EJ, MACROMOLECULES, Vol. 36, 2003, Pages 3563-2567
“Design and synthesis of hydroxyapatite composites containing a PEG-dendritic poly(L-lysine) star polycaprolactone,” Boduch-Lee KA, Chapman TM, Petricca S, Marra K, Kumta P, PMSE PREPRINTS, Vol. 89, 2003, Pages 570-571
“Synthesis and characterization of hyperbranched polylysine,” Menz TL, Chapman TM, POLYMER PREPRINTS, Vol. 44, 2003, Pages 842-843
“Easily grafted polyurethanes with reactive main chain functional groups. Synthesis, characterization, and antithrombogenicity of poly(ethylene glycol)-grafted poly(urethanes),” Orban JM, Chapman TM, Wagner WR, Jankowski R, JOURNAL OF POLYMER SCIENCE PART A-POLYMER CHEMISTRY, Vol. 37, 1999, Pages 3441-3449