Department of Chemistry

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Tara Meyer

Associate Professor

Contact

1005 CHVRN
Chevron Science Center, 219 Parkman Avenue

Pittsburgh, PA 15260
412-624-8635

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Research Overview

Inorganic / Organometallic / Polymers / Biomedical Materials

We are interested in exploiting catalysis in the synthesis of both small molecules and polymers. 

Synthesis of repeating sequence copolymers for biomedical applications

The preparation of plastics that behave like metals is one of the most exciting frontiers of polymer chemistry. We are interested in using metal-catalyzed couplings to assemble polymers with conducting and magnetic properties. A specific system that we are currently investigating involves the preparation of polyanilines with unique architectures. By studying a variety of these materials we hope to develop a set of structure/property relationships that will contribute to the development of new technologies, such as transparency-thin displays and LED's.

One pot reactions that form both new carbon-carbon and carbon-heteroatom bonds

Although the ability of transition metals to catalyze regio- and stereoselective carbon-carbon bond formation is widely exploited, only recently have researchers truly begun to take advantage of the power of transition metals to make carbon-heteroatom bonds, particularly bonds to more ìexoticî main group elements from rows 3 and below in the periodic table. We have recently developed and reported a new palladium catalyzed regio- and stereo- selective chalcogenide-element addition (Y = Se, G = N) to terminal alkynes in the presence of carbon monoxide producing ‚-selenyl acrylamides. Typical yields are 65-85%. The selenyl group, of course, provides many opportunities for subsequent functionalization. The modularity of the reaction is particularly appealing because it could easily allow for the creation of a small library of closely related derivatives. The reaction tolerates a range of alkynyl substrates as well as differing substitutions on the sulfenamide nitrogen. 

Synthesis of conducting and magnetic polymers

Bone tissue engineering has the potential to heal difficult fractures, particularly those associated with diseases such as osteoporosis. The development of good scaffolds is critical to the success this treatment. Ideally these scaffolds should provide mechanical support, encourage proper cell differentiation and proliferation, and degrade to give non-toxic by-products. The need for biocompatibility severely limits the types of monomers that can be used in the synthesis of polymeric biomaterials used as temporary scaffolds in tissue engineering. It is, therefore, attractive to develop materials with a wide range of mechanical properties made from multiple combinations of building blocks that are known to be non-toxic. The most widely used scaffolding to date are polymers derived from lactic and glycolic acids and their copolymers. These materials are FDA-approved for a variety of uses in the human body and are known to degrade hydrolytically to their biocompatible components. Although a wide variety of polymers and copolymers are known for these monomers, there has never been an attempt to examine repeating sequence copolymers (RSC) where the block size is small i.e. (GGGLLLLL)n or (GLLLLLL) (G = glycolic acid monomer, L = lactic acid monomer). There are several advantages to RSC's including uniformity of hydrolytic degradation; the potential to add regularly spaced tethered groups; and the improvement of mechanical properties.

 

Awards

  • NSF CAREER Award, 1996-99
  • NSF POWER Award, 1997-98
  • DuPont Educational Aid Awardee, 1997-99
  • Alfred P. Sloan Fellowship, 1999-2001

Publications

“Iterative Synthesis of Heterotelechelic Oligo(phenylene-vinylene)s by Olefin Cross-Metathesis,” Norris BN, Pan TQ, Meyer TY, Organic Letters, Vol. 12, 2010, Pages 5514-5517
“New Insights into Poly(lactic-co-glycolic acid) Microstructure: Using Repeating Sequence Copolymers To Decipher Complex NMR and Thermal Behavior,” Stayshich RM, Meyer TY, Journal of the American Chemical Society, Vol. 132, 2010, Pages 10920-10934
“Mono- and Terfluorene Oligomers as Versatile Sensitizers for the Luminescent Eu3+ Cation,” Oxley DS, Walters RW, Copenhafer JE, Meyer TY, Petoud S, Edenborn HM, INORGANIC CHEMISTRY, Vol. 48, 2009, Pages 6332-6334
“Preparation and microstructural analysis of poly(lactic-alt-glycolic acid),” Stayshich RM, Meyer TY, JOURNAL OF POLYMER SCIENCE PART A-POLYMER CHEMISTRY, Vol. 46, 2008, Pages 4704-4711
“Synthesis and characterization of repeating sequence copolymers of fluorene and methylene monomers,” Copenhafer JE, Walters RW, Meyer TY, MACROMOLECULES, Vol. 41, 2008, Pages 31-35
“A palladium-catalyzed regio- and stereoselective four-component coupling reaction,” Knapton DJ, Meyer TY, JOURNAL OF ORGANIC CHEMISTRY, Vol. 70, 2005, Pages 785-796
“Proton as the simplest of all catalysts for [2+2] cycloadditions: DFT study of acid-catalyzed imine metathesis,” Burland MC, Meyer TY, Baik MH, JOURNAL OF ORGANIC CHEMISTRY, Vol. 69, 2004, Pages 6173-6184
“The Stereoselective and Catalytic One Pot Synthesis of â-Selanyl Acrylamides,” Knapton DJ, Meyer TY, ORGANIC LETTERS, Vol. 6, 2004, Pages 687-689
“o,p-polyaniline: A new form of a classic conducting polymer,” Ward RE, Meyer TY, MACROMOLECULES, Vol. 36, 2003, Pages 4668-4373
“Iminophosphorane Mediated Imine Metathesis,” Burland MC, Meyer TY, INORGANIC CHEMISTRY, Vol. 42, 2003, Pages 3438-3444
“Dichloro(isopropylamido)bis(isopropylamine)(isopropylimido)-tantalum(V), a monomeric Ta-V compound with imido, amido and amino moieties,” Burland MC, Meyer TY, Geib SJ, ACTA CRYSTALLOGRAPHICA SECTION C-CRYSTAL STRUCTURE COMMUNICATIONS, Vol. 59, 2003, Pages M46-M48
“Catalytic double-bond metathesis without the transition metal,” Bell SA, Meyer TY, Geib SJ, JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, Vol. 124, 2002, Pages 10698-10705